Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups from 4 Days to 19 Years

Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years.

BACKGROUND Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year. METHODS Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children, ages 4 days to 19 years. ...

متن کامل

Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive and Psychological Markers in Elderly in Northeastern of Iran

Objective(s): Incidence of neurocognitive and psychological disorders may be related to serum homocystein (Hcy), cobalamin (vitamin B12 ) and folate levels in old people. The aim of this study was to assess the relation between Hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly. Materials and Methods: In this cross-sectional study, 280 subjects with ...

متن کامل

To the editor: Cobalamin-responsive disorders and unreliability of cobalamin, methylmalonic acid, and homocysteine testing

Solomon1 claims that many patients with clinical features suggestive of cobalamin (Cbl) deficiency who have normal serum Cbl, methylmalonic acid (MMA), and homocysteine (HCys) levels may respond to Cbl therapy, while many patients with low serum Cbl, high serum MMA, or high serum HCys levels may fail to respond to Cbl therapy. He concludes that these tests are unreliable for the diagnosis of Cb...

متن کامل

Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing.

Early recognition of cobalamin (Cbl)-responsive disorders in the ambulatory care setting is essential to prevent irreversible neurologic deficits. However, diagnostic algorithms using Cbl, methylmalonic acid (MMA), and homocysteine (HCys) measurements reflect studies in academic centers, and their negative predictive values have not been established. Thus, records of 456 ambulatory patients eva...

متن کامل

Cobalamin-responsive disorders and unreliability of cobalamin, methylmalonic acid, and homocysteine testing.

Solomon1 claims that many patients with clinical features suggestive of cobalamin (Cbl) deficiency who have normal serum Cbl, methylmalonic acid (MMA), and homocysteine (HCys) levels may respond to Cbl therapy, while many patients with low serum Cbl, high serum MMA, or high serum HCys levels may fail to respond to Cbl therapy. He concludes that these tests are unreliable for the diagnosis of Cb...

متن کامل

Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups from 4 Days to 19 Years

نویسندگان

چکیده

منابع مشابه